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Limbic Kindling

Limbic kindling is a condition where either repeated neurological exposure to  a sub-threshold stimulus (i.e. one that does not produce problems), or a short-term high intensity stimulus (e.g. brain trauma), eventually leads to a persistent hypersensitivity to that stimulus.

Kindling was originally discovered in 1967 by Graham Goddard while studying the effects of electrical stimulation of the amygdaloid complex in the brain on learning in rats.(1) Similar to the work of Eric Kandel, he found that long-term, low intensity and intermittent electric shocks to their brains caused rats have spontaneous, epileptic-like seizures – even when no stimulation was given. 

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